Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
Author(s) -
Jill V. Hunter,
A. Campbell,
Jacqueline Butterworth,
Hélène Sellier,
Nicola Hannaway,
Saimir Luli,
Achilleas Floudas,
Niall S. Kenneth,
Adam J. Moore,
Philip Brownridge,
Huw D. Thomas,
Jonathan Coxhead,
Leigh Taylor,
Peter Leary,
Megan Hasoon,
Andrew M. Knight,
Michelle D. Garrett,
Ian Collins,
Claire E. Eyers,
Neil D. Perkins
Publication year - 2022
Publication title -
biochemical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.706
H-Index - 265
eISSN - 1470-8728
pISSN - 0264-6021
DOI - 10.1042/bcj20220089
Subject(s) - biology , dna damage , transactivation , cancer research , dna replication factor cdt1 , regulator , dna replication , transcription factor , microbiology and biotechnology , dna , gene , eukaryotic dna replication , genetics
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