Hydrogen sulfide in ageing, longevity and disease | Zendy

Stephen E. Wilkie | Zendy; Gillian Borland | Zendy; Roderick N. Carter | Zendy; Nicholas M. Morton | Zendy; Colin Selman | Zendy

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Hydrogen sulfide in ageing, longevity and disease

Author(s) -

Stephen E. Wilkie,

Gillian Borland,

Roderick N. Carter,

Nicholas M. Morton,

Colin Selman

Publication year - 2021

Publication title -

biochemical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.706

H-Index - 265

eISSN - 1470-8728

pISSN - 0264-6021

DOI - 10.1042/bcj20210517

Subject(s) - longevity , context (archaeology) , ageing , hydrogen sulfide , mediator , disease , biology , chemistry , medicine , gerontology , microbiology and biotechnology , pathology , genetics , paleontology , sulfur , organic chemistry

Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies.

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