Node of Ranvier Disruption as a Cause of Neurological Diseases | Zendy

Keiichiro Susuki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Node of Ranvier Disruption as a Cause of Neurological Diseases

Author(s) -

Keiichiro Susuki

Publication year - 2013

Publication title -

asn neuro

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.039

H-Index - 45

ISSN - 1759-0914

DOI - 10.1042/an20130025

Subject(s) - axolemma , node of ranvier , neuroscience , nodal , ion channel , axon , biology , neuroscientist , sodium channel , oligodendrocyte , myelin , chemistry , central nervous system , anatomy , genetics , receptor , organic chemistry , sodium

Dysfunction and/or disruption of nodes of Ranvier are now recognized as key contributors to the pathophysiology of various neurological diseases. One reason is that the excitable nodal axolemma contains a high density of Nav (voltage-gated Na+ channels) that are required for the rapid and efficient saltatory conduction of action potentials. Nodal physiology is disturbed by altered function, localization, and expression of voltage-gated ion channels clustered at nodes and juxtaparanodes, and by disrupted axon-glial interactions at paranodes. This paper reviews recent discoveries in molecular/cellular neuroscience, genetics, immunology, and neurology that highlight the critical roles of nodes of Ranvier in health and disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research