Samarium diiodide promoted coupling of thiophenecarbaldehydes | Zendy

ShyhMing Yang | Zendy; JimMin Fang | Zendy

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Samarium diiodide promoted coupling of thiophenecarbaldehydes

Author(s) -

ShyhMing Yang,

JimMin Fang

Publication year - 1995

Publication title -

journal of the chemical society. perkin transactions i/journal of the chemical society. perkin transactions. i

Language(s) - English

Resource type - Journals

eISSN - 2050-8255

pISSN - 0300-922X

DOI - 10.1039/p19950002669

Subject(s) - samarium diiodide , thiophene , chemistry , samarium , hexamethylphosphoramide , coupling reaction , alkylation , naphthalene , medicinal chemistry , photochemistry , organic chemistry , catalysis

Thiophene-2-carbaldehyde adds to aromatic and aliphatic aldehydes with the mediation of samarium diiodide and hexamethylphosphoramide. These hydroxyalkylations occur at the 5-position of thiophene-2-carbaldehyde. The self- and cross-coupling reactions of thiophene-3-carbaldehyde occur at the 2-position. S-Alkylation of the reaction intermediates gives substituted γ-lactols.

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