β-Lactam and penicillin substituted mesoionic metal carbene complexes | Zendy

Marta G. Avello | Zendy; María Moreno-Latorre | Zendy; Marı́a C. de la Torre | Zendy; Luis Casarrubios | Zendy; Heinz Gornitzka | Zendy; Catherine Hemmert | Zendy; Miguel Á. Sierra | Zendy

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β-Lactam and penicillin substituted mesoionic metal carbene complexes

Author(s) -

Marta G. Avello,

María Moreno-Latorre,

Marı́a C. de la Torre,

Luis Casarrubios,

Heinz Gornitzka,

Catherine Hemmert,

Miguel Á. Sierra

Publication year - 2022

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/d2ob00216g

Subject(s) - mesoionic , chemistry , regioselectivity , transmetalation , cycloisomerization , carbene , ring (chemistry) , triazole , penicillin , medicinal chemistry , catalysis , alkylation , alkyne , stereochemistry , combinatorial chemistry , organic chemistry , antibiotics , biochemistry

1,2,3-Triazolylidene MIC M-complexes (M = Au, Pd, Pt) having 2-azetidinones and penicillin G substituents at the triazole ring were prepared by CuAAC on 2-azetidinones having a terminal alkyne tethered at N1, followed by alkylation of the 1,2,3-triazole ring and transmetallation [Au(I), Pd(II) and Pt(II)]. The Au-MIC complexes efficiently catalyze the regioselective cycloisomerization of enynes, while the Pt-MIC complexes were efficient catalysts in hydrosilylation reactions.

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