Enantioselective hydrophosphonylation of N-Boc imines using chiral guanidine–thiourea catalysts | Zendy

Louis Chassillan | Zendy; Yasuhiro Yamashita | Zendy; WooJin Yoo | Zendy; Martial Toffano | Zendy; Régis Guillot | Zendy; Shū Kobayashi | Zendy; Giang VoThanh | Zendy

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Enantioselective hydrophosphonylation of N-Boc imines using chiral guanidine–thiourea catalysts

Author(s) -

Louis Chassillan,

Yasuhiro Yamashita,

WooJin Yoo,

Martial Toffano,

Régis Guillot,

Shū Kobayashi,

Giang VoThanh

Publication year - 2021

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/d1ob01953h

Subject(s) - thiourea , chemistry , enantioselective synthesis , guanidine , catalysis , styrene , polymerization , organic chemistry , combinatorial chemistry , polymer chemistry , polymer , copolymer

The enantioselective hydrophosphonylation of N -Boc imines was investigated using a new family of pseudo-symmetric guanidine-thiourea catalysts, providing α-amino phosphonates in moderate to high yields with good enantioselectivity. The catalyst was heterogenized by polymerization with styrene and the resulting catalyst was applied to reactions under continuous-flow conditions.

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