Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues | Zendy

Chao Liu | Zendy; Ruiqi Zhao | Zendy; Liangliang Song | Zendy; Zhenghua Li | Zendy; Guilong Tian | Zendy; Yi He | Zendy; Luc Van Meervelt | Zendy; Vsevolod A. Peshkov | Zendy; Erik V. Van der Eycken | Zendy

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Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues

Author(s) -

Chao Liu,

Ruiqi Zhao,

Liangliang Song,

Zhenghua Li,

Guilong Tian,

Yi He,

Luc Van Meervelt,

Vsevolod A. Peshkov,

Erik V. Van der Eycken

Publication year - 2021

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/d1ob01805a

Subject(s) - chemistry , palladium , intramolecular force , michael reaction , ugi reaction , adduct , combinatorial chemistry , cascade , catalysis , stereochemistry , isocyanide , organic chemistry , chromatography

A palladium-catalyzed intramolecular cyclization of Ugi-adducts via a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.

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