Synthesis of N-CF3 hydrazines through radical trifluoromethylation of azodicarboxylates | Zendy

Tingting Cao | Zendy; Pascal Retailleau | Zendy; Thierry Milcent | Zendy; Benoı̂t Crousse | Zendy

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Synthesis of N-CF₃ hydrazines through radical trifluoromethylation of azodicarboxylates

Author(s) -

Tingting Cao,

Pascal Retailleau,

Thierry Milcent,

Benoı̂t Crousse

Publication year - 2021

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d1cc04538e

Subject(s) - trifluoromethylation , reagent , chemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , trifluoromethyl , alkyl

We report here the synthesis of a novel family of N -CF 3 hydrazines from a direct way involving the available and cheap Langlois reagent (CF 3 SO 2 Na). These derivatives have shown very high stability whatever the conditions used and are excellent precursors for building previously inaccessible N -CF 3 functionalized compounds, such as substituted hydrazides, hydrazine-amino-acids, hydrazones, N -aziridines and pyrazoles.

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