3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions | Zendy

Madeleine Cauwel | Zendy; C. Le Guillou | Zendy; Kévin Renault | Zendy; Damien Schapman | Zendy; Magalie Bénard | Zendy; Ludovic Galas | Zendy; Pascal Cosette | Zendy; PierreYves Renard | Zendy; Cyrille Sabot | Zendy

Open Access

3-Benzoylquinoxalinone as a photoaffinity labelling derivative with fluorogenic properties allowing reaction monitoring under “no-wash” conditions

Author(s) -

Madeleine Cauwel,

C. Le Guillou,

Kévin Renault,

Damien Schapman,

Magalie Bénard,

Ludovic Galas,

Pascal Cosette,

PierreYves Renard,

Cyrille Sabot

Publication year - 2021

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d1cc01072g

Subject(s) - labelling , derivative (finance) , photoaffinity labeling , chemistry , affinity label , combinatorial chemistry , fluorescent labelling , fluorescence , stereochemistry , biochemistry , binding site , physics , quantum mechanics , financial economics , economics

Described herein is a quinoxalinone-based photoaffinity probe with caged fluorescence properties. Upon visible blue LED irradiation (λ max 450 nm), this photo-crosslinker is able to covalently capture proteins with concomitant fluorescence labelling. This process enables monitoring applications under "no wash" conditions.

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