Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes | Zendy

Julia A. Zakashansky | Zendy; Amanda Hikari Imamura | Zendy; Darwin F. Salgado | Zendy; Heather C. Romero Mercieca | Zendy; Raphael F. L. Aguas | Zendy; Angelou M. Lao | Zendy; Joseph J. Pariser | Zendy; Netzahualcóyotl ArroyoCurrás | Zendy; Michelle Khine | Zendy

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Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes

Author(s) -

Julia A. Zakashansky,

Amanda Hikari Imamura,

Darwin F. Salgado,

Heather C. Romero Mercieca,

Raphael F. L. Aguas,

Angelou M. Lao,

Joseph J. Pariser,

Netzahualcóyotl ArroyoCurrás,

Michelle Khine

Publication year - 2021

Publication title -

analytical methods

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.615

H-Index - 67

eISSN - 1759-9679

pISSN - 1759-9660

DOI - 10.1039/d1ay00041a

Subject(s) - saliva , spike protein , spike (software development) , covid-19 , chromatography , virology , chemistry , biology , computer science , medicine , biochemistry , outbreak , disease , software engineering , infectious disease (medical specialty)

Using the children's toy, Shrinky-Dink©, we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 1 ag mL-1 of the S1 subunit of the spike protein.

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