Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity? | Zendy

Sachin Katti | Zendy; Tatyana I. Igumenova | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?

Author(s) -

Sachin Katti,

Tatyana I. Igumenova

Publication year - 2020

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/d0mt00002g

Subject(s) - obstacle , buffer (optical fiber) , interference (communication) , domain (mathematical analysis) , chemistry , chemical engineering , computer science , telecommunications , engineering , political science , channel (broadcasting) , mathematical analysis , mathematics , law

Pb 2+ is a xenobiotic metal ion that competes for Ca 2+ -binding sites in proteins. Using the peripheral Ca 2+ -sensing domains of Syt1, we show that the chelating pH buffer Bis-Tris enables identification and functional characterization of high-affinity Pb 2+ sites that are likely to be targeted by bioavailable Pb 2+ .

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research