A novel minimal motif for left-handed G-quadruplex formation | Zendy

Poulomi Das | Zendy; Fernaldo Richtia Winnerdy | Zendy; Arijit Maity | Zendy; Yves Mechulam | Zendy; Anh Tuân Phan | Zendy

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A novel minimal motif for left-handed G-quadruplex formation

Author(s) -

Poulomi Das,

Fernaldo Richtia Winnerdy,

Arijit Maity,

Yves Mechulam,

Anh Tuân Phan

Publication year - 2021

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc08146a

Subject(s) - motif (music) , g quadruplex , structural motif , thymine , stereochemistry , chemistry , crystallography , dna , physics , biochemistry , acoustics

A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

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