Open AccessDelivery of siRNA by tailored cell-penetrating urea-based foldamers
Author(s) -
Mégane Bornerie,
Anaïs Brion,
Gilles Guichard,
Antoine Kichler,
Céline Douat
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc06285e
Subject(s) - chemistry , urea , cell , combinatorial chemistry , nanotechnology , biochemistry , materials science
Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA.
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