Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex | Zendy

Émilie Mathieu | Zendy; Anne-Sophie Bernard | Zendy; Elodie Quévrain | Zendy; Martha Zoumpoulaki | Zendy; Sébastien Iriart | Zendy; Caroline Lung-Soong | Zendy; Barry Lai | Zendy; Kadda Medjoubi | Zendy; Lucas P. Henry | Zendy; Sounderya Nagarajan | Zendy; Florent Poyer | Zendy; Andreas Scheitler | Zendy; Ivana IvanovićBurmazović | Zendy; Sergio Marco | Zendy; Andréa Somogyi | Zendy; Philippe Seksik | Zendy; Nicolas Delsuc | Zendy; Clotilde Policar | Zendy

Open Access

Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex

Author(s) -

Émilie Mathieu,

Anne-Sophie Bernard,

Elodie Quévrain,

Martha Zoumpoulaki,

Sébastien Iriart,

Caroline Lung-Soong,

Barry Lai,

Kadda Medjoubi,

Lucas P. Henry,

Sounderya Nagarajan,

Florent Poyer,

Andreas Scheitler,

Ivana IvanovićBurmazović,

Sergio Marco,

Andréa Somogyi,

Philippe Seksik,

Nicolas Delsuc,

Clotilde Policar

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc03398g

Subject(s) - superoxide dismutase , intracellular , chemistry , superoxide , oxidative stress , manganese , mitochondrion , biochemistry , rationalization (economics) , microbiology and biotechnology , enzyme , biology , philosophy , organic chemistry , epistemology

A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.

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