Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization | Zendy

Le Yu | Zendy; Jun Feng Zhang | Zendy; Mingle Li | Zendy; Dewei Jiang | Zendy; Ying Zhou | Zendy; Peter Verwilst | Zendy; Jong Seung Kim | Zendy

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Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

Author(s) -

Le Yu,

Jun Feng Zhang,

Mingle Li,

Dewei Jiang,

Ying Zhou,

Peter Verwilst,

Jong Seung Kim

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc02943b

Subject(s) - intramolecular force , visualization , conjugate , viscosity , biophysics , fluorescence , chemistry , computer science , physics , biology , artificial intelligence , stereochemistry , optics , thermodynamics , mathematics , mathematical analysis

We report a novel fluorescent molecular conjugate, V-M1, enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, which is well within the near-infrared therapeutic window. Tumor accumulation of this cationic dye allows the visualization of cancerous cells as a function of mitochondrial viscosity.

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