Open AccessRegio- and diastereoselective Pd-catalyzed synthesis of C2-aryl glycosides
Author(s) -
Juba Ghouilem,
Rémi Franco,
Pascal Retailleau,
Mouâd Alami,
Vincent Gandon,
Samir Messaoudi
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc02175j
Subject(s) - aryl , catalysis , chemistry , glycoside , palladium , combinatorial chemistry , organic chemistry , alkyl
An efficient regio- and diastereoselective arylation method of readily available 2,3-glycals with various aryl iodides has been established. Using the Pd(OAc)2/AsPh3 precatalytic system, this protocol proved to be general to prepare a variety of substituted C2-aryl glycosides in good yields with complete diastereoselectivity.
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