Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation | Zendy

Patricia E. Krach | Zendy; Abhishek Dewanji | Zendy; Tingting Yuan | Zendy; Magnus Rueping | Zendy

Open Access

Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation

Author(s) -

Patricia E. Krach,

Abhishek Dewanji,

Tingting Yuan,

Magnus Rueping

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc01480j

Subject(s) - acylation , benzophenone , chemistry , catalysis , toluene , nickel , combinatorial chemistry , ketone , organic chemistry , photochemistry

Herein, we report a dual catalytic system for the direct benzylic C-H acylation reaction furnishing a variety of unsymmetrical ketones. A benzophenone-derived photosensitizer combined with a nickel catalyst has been established as the catalytic system. Both acid chlorides and anhydrides are able to acylate the benzylic position of toluene and other methylbenzenes. The method offers a valuable alternative to late transition metal catalyzed C-H acylation reactions.

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