Electrochemical nickel-catalyzed Migita cross-coupling of 1-thiosugars with aryl, alkenyl and alkynyl bromides | Zendy

Mingxiang Zhu | Zendy; Mouâd Alami | Zendy; Samir Messaoudi | Zendy

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Electrochemical nickel-catalyzed Migita cross-coupling of 1-thiosugars with aryl, alkenyl and alkynyl bromides

Author(s) -

Mingxiang Zhu,

Mouâd Alami,

Samir Messaoudi

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc01126f

Subject(s) - aryl , electrochemistry , catalysis , chemistry , glycosidic bond , nickel , combinatorial chemistry , coupling reaction , base (topology) , organic chemistry , alkyl , electrode , mathematical analysis , mathematics , enzyme

Here we report a simple route towards the synthesis of thioglycosides, in which electrochemical cross-coupling is used to form a S-C glycosidic bond from protected and unprotected thiosugars with functionalized aryl bromides under base free conditions. The reaction manifold that we report here demonstrates the power of electrochemistry to access highly complex glycosides under mild conditions.

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