Enantioselective gold(i)-catalyzed cyclization/intermolecular nucleophilic additions of 1,5-enyne derivatives | Zendy

Xu Han | Zendy; Pascal Retailleau | Zendy; Vincent Gandon | Zendy; Arnaud Voituriez | Zendy

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Enantioselective gold(i)-catalyzed cyclization/intermolecular nucleophilic additions of 1,5-enyne derivatives

Author(s) -

Xu Han,

Pascal Retailleau,

Vincent Gandon,

Arnaud Voituriez

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc00914h

Subject(s) - enantioselective synthesis , enyne , nucleophile , catalysis , intermolecular force , chemistry , combinatorial chemistry , nucleophilic addition , organic chemistry , stereochemistry , medicinal chemistry , molecule

An enantioselective Au(i)-catalyzed cyclization/nucleophilic addition process is developed, starting from 1,5-enyne substrates. A broad scope of O-, N- and C-nucleophiles was introduced in order to provide the corresponding chiral cyclopentene derivatives in moderate to high yields and up to 96 : 4 enantiomeric ratio.

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