A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery
Author(s) -
MohammadAli Shahbazi,
Neha Shrestha,
Małgorzata Karolina Pierchała,
Firoz Babu Kadumudi,
Mehdi Mehrali,
Masoud Hasany,
Véronique Préat,
Sander C.G. Leeuwenburgh,
Alireza DolatshahiPirouz
Publication year - 2020
Publication title -
journal of materials chemistry b
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.316
H-Index - 101
eISSN - 2050-7518
pISSN - 2050-750X
DOI - 10.1039/c9tb02156f
Subject(s) - biomaterial , materials science , drug delivery , self healing , biomedical engineering , wearable computer , nanotechnology , medicine , engineering , embedded system , alternative medicine , pathology
One of the long-standing challenges in materials science involves synthesizing biomaterials that recapitulate important features of native biological tissues. Even though, the number of available biomaterials at the moment are virtually limitless, few of them has unlocked all the secrets of the human body by mimicking the combinatorial-like material properties of our tissues and organs. Inspired by the human body, we have developed a polymeric gum, which combines stretchability, toughness, strength, flexibility, and self-healing. It also exhibits a high bioactivity that can target and eliminate bacterial infections fast and reliably. Notably, this material is moldable into almost any complex shape, and therefore suitable as a building block for wearables designed to conform directly with the curved and personalized anatomy of patients. It also exhibits excellent drug retention and release capacity, which altogether makes it suitable for applications in personalized wearable drug-delivery devices.
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