Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy | Zendy

Amandine Oudin | Zendy; Julie Chauvin | Zendy; Laure Gibot | Zendy; MariePierre Rols | Zendy; Stéphanie Balor | Zendy; Dominique Goudounèche | Zendy; Bruno Payré | Zendy; Barbara Lonetti | Zendy; Patricia Vicendo | Zendy; AnneFrançoise Mingotaud | Zendy; Vincent Lapinte | Zendy

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Amphiphilic polymers based on polyoxazoline as relevant nanovectors for photodynamic therapy

Author(s) -

Amandine Oudin,

Julie Chauvin,

Laure Gibot,

MariePierre Rols,

Stéphanie Balor,

Dominique Goudounèche,

Bruno Payré,

Barbara Lonetti,

Patricia Vicendo,

AnneFrançoise Mingotaud,

Vincent Lapinte

Publication year - 2019

Publication title -

journal of materials chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.316

H-Index - 101

eISSN - 2050-7518

pISSN - 2050-750X

DOI - 10.1039/c9tb00118b

Subject(s) - phototoxicity , photodynamic therapy , photosensitizer , nanocarriers , amphiphile , pheophorbide a , polymer , coumarin , methacrylate , materials science , chemistry , singlet oxygen , cytotoxicity , copolymer , combinatorial chemistry , in vitro , nanoparticle , organic chemistry , nanotechnology , biochemistry , oxygen

An amphiphilic polymer (CmPOX) based on poly(2-methyl-2-oxazoline) linked to a hydrophobic part composed of an aliphatic chain ending with a photo-active coumarin group has been synthesized. It exhibits the ability of forming small polymeric self-assemblies, typically of ca. 10 nm in size, which were characterized by TEM, cryo-TEM and DLS. The nanocarriers were further formulated to yield photo-crosslinked systems by dimerization of coumarin units of coumarin-functionalized poly(methyl methacrylate) (CmPMMA) and CmPOX. The formed vectors were used to encapsulate Pheophorbide a, a known photosensitizer for photodynamic therapy. Cytotoxicity as well as phototoxicity experiments performed in vitro on human tumor cells revealed the great potential of these nanovectors for photodynamic therapy.

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