Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules | Zendy

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Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

Author(s) -

Victor Lee

Publication year - 2019

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/c9ob01602c

Subject(s) - chemistry , stille reaction , fluoride , copper , salt (chemistry) , combinatorial chemistry , molecule , organic chemistry , inorganic chemistry , catalysis

The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(i) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018.

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