A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles | Zendy

Arnab Banerjee | Zendy; Vítor Alves | Zendy; Tiago Rondão | Zendy; José Sereno | Zendy; A. Neves | Zendy; Miguel Lino | Zendy; Andreia Ribeiro | Zendy; Antero Abrunhosa | Zendy; Lino Ferreira | Zendy

Open Access

A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Author(s) -

Arnab Banerjee,

Vítor Alves,

Tiago Rondão,

José Sereno,

A. Neves,

Miguel Lino,

Andreia Ribeiro,

Antero Abrunhosa,

Lino Ferreira

Publication year - 2019

Publication title -

nanoscale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.038

H-Index - 224

eISSN - 2040-3372

pISSN - 2040-3364

DOI - 10.1039/c9nr02512j

Subject(s) - positron emission tomography , magnetic resonance imaging , preclinical imaging , brain positron emission tomography , nuclear magnetic resonance , extracellular vesicles , in vivo , materials science , pet imaging , nuclear medicine , biomedical engineering , radiology , physics , medicine , biology , microbiology and biotechnology

Here we report a two-step surface modification methodology to radiolabel small extracellular vesicles (SEVs) with 64CuCl2 for PET/MRI imaging. The modification did not change or damage the morphology, surface receptor proteins and internal RNA content. Radiolabeled SEVs could be detected in organs with low accumulation such as the brain (0.4-0.5% ID g-1) and their brain location determined by MRI.

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