Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis | Zendy

XiuYing Qin | Zendy; Ya-Nan Wang | Zendy; Han-Fu Liu | Zendy; Zhaohui Luo | Zendy; Pei-Lu Zhang | Zendy; Lifang Huang | Zendy; Meirong Liu | Zendy

Open Access

Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis

Author(s) -

XiuYing Qin,

Ya-Nan Wang,

Han-Fu Liu,

Zhaohui Luo,

Pei-Lu Zhang,

Lifang Huang,

Meirong Liu

Publication year - 2019

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c9mt00248k

Subject(s) - apoptosis , angiogenesis , vegf receptors , chemistry , microbiology and biotechnology , signal transduction , cancer research , biology , biochemistry

Three novel single crystals of the metal-based complexes Cu-1, Cu-2, and Co-1 were obtained and characterized. Compared with Cu-2 and Co-1, Cu-1 showed remarkable activities of anti-cervical cancer, anti-cisplatin-resistant non-small cell lung cancer and anti-angiogenesis by downregulating the expressions of important proteins in the VEGF/VEGFR2 signaling pathway to inhibit angiogenesis and cancer cell proliferation, induce apoptosis, and suppress migration and metastasis. Moreover, Cu-1 dramatically inhibited the expression of the anti-apoptotic protein Bcl-2 and up-regulated the expressions of the proapoptotic proteins caspase-9 and Bax to induce the apoptosis of tumor cells, simultaneously decreasing the density of endothelial cells to inhibit tumor angiogenesis in cisplatin-resistant tumors.

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