Open AccessNovel Pt(ii ) complexes with modified aroyl-hydrazone Schiff-base ligands: synthesis, cytotoxicity and action mechanism
Author(s) -
JunGang Deng,
Ping Yu,
Zhenlei Zhang,
Juzheng Zhang,
Sun Zhewen,
Meiling Cai,
Haoliang Yuan,
Hong Liang,
Feng Yang
Publication year - 2019
Publication title -
metallomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 75
eISSN - 1756-591X
pISSN - 1756-5901
DOI - 10.1039/c9mt00193j
Subject(s) - hydrazone , cytotoxicity , chemistry , schiff base , mechanism of action , stereochemistry , apoptosis , dna , telomerase , combinatorial chemistry , biochemistry , in vitro , gene
The complex-induced apoptosis of cancer cells via : (1) the mitochondrial pathway; (2) inserting into and cleaving DNA; and (3) inhibiting telomerase.
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