Open AccessAn oxidatively damaged G-quadruplex/hemin DNAzyme
Author(s) -
Jiawei Wang,
Mingpan Cheng,
Jielin Chen,
Huangxian Ju,
David Monchaud,
JeanLouis Mergny,
Jun Zhou
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c9cc09237d
Subject(s) - deoxyribozyme , hemin , g quadruplex , chemistry , guanine , biophysics , biochemistry , dna , heme , biology , nucleotide , enzyme , gene
Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.
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