Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli | Zendy

Madeleine Cauwel | Zendy; Adeline Sivig | Zendy; Clarisse Bridot | Zendy; Medy C. gbe | Zendy; David Deniaud | Zendy; Benoît Roubinet | Zendy; Ludovic Landemarre | Zendy; FrançoisXavier Felpin | Zendy; Julie Bouckaert | Zendy; Nicolas Barnich | Zendy; Sébastien G. Gouin | Zendy

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Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

Author(s) -

Madeleine Cauwel,

Adeline Sivig,

Clarisse Bridot,

Medy C. gbe,

David Deniaud,

Benoît Roubinet,

Ludovic Landemarre,

FrançoisXavier Felpin,

Julie Bouckaert,

Nicolas Barnich,

Sébastien G. Gouin

Publication year - 2019

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c9cc05545b

Subject(s) - cellulose , bacterial adhesin , covalent bond , nanofiber , escherichia coli , chemistry , combinatorial chemistry , materials science , nanotechnology , biochemistry , organic chemistry , gene

We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.

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