Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide | Zendy

Hiroshi Inaba | Zendy; Takahisa Yamamoto | Zendy; Takashi Iwasaki | Zendy; Arif Md. Rashedul Kabir | Zendy; Akira Kakugo | Zendy; Kazuki Sada | Zendy; Kazunori Matsuura | Zendy

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Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide

Author(s) -

Hiroshi Inaba,

Takahisa Yamamoto,

Takashi Iwasaki,

Arif Md. Rashedul Kabir,

Akira Kakugo,

Kazuki Sada,

Kazunori Matsuura

Publication year - 2019

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c9cc04345d

Subject(s) - microtubule , encapsulation (networking) , peptide , chemistry , biophysics , green fluorescent protein , microbiology and biotechnology , biochemistry , computer science , biology , gene , computer network

We constructed GFP-encapsulated microtubules (MTs) using a Tau-derived peptide which binds to their interior. The encapsulation of the GFP dramatically increased the rigidity of MTs, resulting in their enhanced velocity on a kinesin-coated substrate. Moreover, the GFP-encapsulated MTs were significantly more stable than normal MTs.

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