Open AccessA fluorogenic BODIPY molecular rotor as an apoptosis marker
Author(s) -
Pichandi Ashokkumar,
Anila Hoskere Ashoka,
Mayeul Collot,
Amitava Das,
Andrey S. Klymchenko
Publication year - 2019
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c9cc03242h
Subject(s) - bodipy , apoptosis , rotor (electric) , chemistry , biochemistry , biophysics , fluorescence , computational biology , biology , physics , quantum mechanics
Based on a BODIPY molecular rotor and a zinc-dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.
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