Reinforced Ni(ii)-cyclam derivatives as dual1H/19F MRI probes | Zendy

Rosa Pujales–Paradela | Zendy; Tanja Savić | Zendy; Isabel Brandariz | Zendy; P. PérezLourido | Zendy; Goran Angelovski | Zendy; David EstebanGómez | Zendy; Carlos PlatasIglesias | Zendy

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Reinforced Ni(ii)-cyclam derivatives as dual¹H/¹⁹F MRI probes

Author(s) -

Rosa Pujales–Paradela,

Tanja Savić,

Isabel Brandariz,

P. PérezLourido,

Goran Angelovski,

David EstebanGómez,

Carlos PlatasIglesias

Publication year - 2019

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c9cc01204d

Subject(s) - cyclam , chemistry , crystallography , metal , organic chemistry

Reinforced cross-bridged Ni2+-cyclam complexes were functionalised with pendant arms containing both amide protons and CF3 groups that lead to a dual 1H/19F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni2+ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in 19F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.

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