Open AccessC–H 18F-fluorination of 8-methylquinolines with Ag[18F]F
Author(s) -
So Jeong Lee,
Allen F. Brooks,
Naoko Ichiishi,
Katarina J. Makaravage,
Andrew V. Mossine,
Melanie S. Sanford,
Peter J. H. Scott
Publication year - 2019
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c9cc00641a
Subject(s) - chemistry , cartridge , combinatorial chemistry , radiochemistry , materials science , metallurgy
This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.