C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F | Zendy

So Jeong Lee | Zendy; Allen F. Brooks | Zendy; Naoko Ichiishi | Zendy; Katarina J. Makaravage | Zendy; Andrew V. Mossine | Zendy; Melanie S. Sanford | Zendy; Peter J. H. Scott | Zendy

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C–H ¹⁸F-fluorination of 8-methylquinolines with Ag[¹⁸F]F

Author(s) -

So Jeong Lee,

Allen F. Brooks,

Naoko Ichiishi,

Katarina J. Makaravage,

Andrew V. Mossine,

Melanie S. Sanford,

Peter J. H. Scott

Publication year - 2019

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c9cc00641a

Subject(s) - chemistry , cartridge , combinatorial chemistry , materials science , metallurgy

This report describes a Pd-mediated C-H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C-H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.

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