Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles | Zendy

Sul Hwa Yu | Zendy; Malay Patra | Zendy; Stefano Ferrari | Zendy; Paulina D. Ramírez-García | Zendy; Nicholas A. Veldhuis | Zendy; Lisa M. Kaminskas | Zendy; Bim Graham | Zendy; John F. Quinn | Zendy; Michael R. Whittaker | Zendy; Gilles Gasser | Zendy; Thomas P. Davis | Zendy

Open Access

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Author(s) -

Sul Hwa Yu,

Malay Patra,

Stefano Ferrari,

Paulina D. Ramírez-García,

Nicholas A. Veldhuis,

Lisa M. Kaminskas,

Bim Graham,

John F. Quinn,

Michael R. Whittaker,

Gilles Gasser,

Thomas P. Davis

Publication year - 2018

Publication title -

journal of materials chemistry b

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.316

H-Index - 101

eISSN - 2050-7518

pISSN - 2050-750X

DOI - 10.1039/c8tb02464b

Subject(s) - phototoxicity , rhenium , nanoparticle , core (optical fiber) , linker , polymer , cervical cancer , star (game theory) , lanthanide , materials science , nanotechnology , chemical engineering , chemistry , polymer chemistry , cancer , organic chemistry , computer science , biology , biochemistry , physics , composite material , astrophysics , engineering , in vitro , ion , genetics , operating system

We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(i) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N'-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(i) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations.

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