Teratogen screening with human pluripotent stem cells | Zendy

Kathryn E. Worley | Zendy; Jennifer RicoVarela | Zendy; Dominic Ho | Zendy; Leo Q. Wan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Teratogen screening with human pluripotent stem cells

Author(s) -

Kathryn E. Worley,

Jennifer RicoVarela,

Dominic Ho,

Leo Q. Wan

Publication year - 2018

Publication title -

integrative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.853

H-Index - 70

eISSN - 1757-9708

pISSN - 1757-9694

DOI - 10.1039/c8ib00082d

Subject(s) - induced pluripotent stem cell , embryoid body , teratology , organoid , biology , developmental toxicity , embryonic stem cell , computational biology , microbiology and biotechnology , genetics , fetus , pregnancy , gene

Birth defects are a common occurrence in the United States and worldwide. Currently, evaluation of potential developmental toxicants (i.e., teratogens) relies heavily on animal-based models which do not always adequately mimic human development. In order to address this, researchers are developing in vitro human-based models which utilize human pluripotent stem cells (hPSCs) to assess the teratogenic potential of chemical substances. The field of human developmental toxicity assays includes a variety of platforms including monolayer, micropattern, embryoid body, and 3D organoid cultures. In this review, we will overview the field of human teratogenic assays, detail the most recent advances, and discuss current limitations and future perspectives.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research