Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease | Zendy

Angela B. Seddon | Zendy; Bruce Napier | Zendy; Ian Lindsay | Zendy; Samir Lamrini | Zendy; Peter M. Moselund | Zendy; Nicholas Stone | Zendy; Ole Bang | Zendy; M.C. Farries | Zendy

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Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Author(s) -

Angela B. Seddon,

Bruce Napier,

Ian Lindsay,

Samir Lamrini,

Peter M. Moselund,

Nicholas Stone,

Ole Bang,

M.C. Farries

Publication year - 2018

Publication title -

the analyst

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.998

H-Index - 153

eISSN - 1364-5528

pISSN - 0003-2654

DOI - 10.1039/c8an01396a

Subject(s) - supercontinuum , in vivo , mid infrared , optics , infrared , laser , optical fiber , medicine , biology , physics , genetics , photonic crystal fiber

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the 'fingerprint region'.

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