The failure of rodent carcinogenesis as a model for Man | Zendy

Colin Berry | Zendy

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The failure of rodent carcinogenesis as a model for Man

Author(s) -

Colin Berry

Publication year - 2017

Publication title -

toxicology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.709

H-Index - 31

eISSN - 2045-4538

pISSN - 2045-452X

DOI - 10.1039/c7tx00283a

Subject(s) - epigenetics , carcinogenesis , genetic model , process (computing) , realisation , rodent model , promotion (chess) , sequence (biology) , rodent , biology , computational biology , genetics , computer science , political science , cancer , ecology , gene , physics , quantum mechanics , politics , law , operating system , endocrinology

Recent advances in our understanding of the process of carcinogenesis in Man have required revision of our thinking about the classical initiation/promotion sequence; understanding must now encompass the roles of both genetic and epigenetic change, realisation of the importance of the variable genetic backgrounds of the tumour bearers in any group and an understanding of the importance of random genetic events over time. The behavior of tumours, once established, is more complex than has been thought. Current views of the processes involved are not modelled in toxicity testing programmes.

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