Open AccessGenotoxicity of ortho-quinones: reactive oxygen species versus covalent modification
Author(s) -
T.M. Penning
Publication year - 2017
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c7tx00223h
Subject(s) - genotoxicity , chemistry , carcinogenesis , reactive oxygen species , estrogen , carcinogen , covalent bond , organic chemistry , environmental chemistry , biochemistry , biology , genetics , toxicity , gene
o -Quinones are formed metabolically from natural and synthetic estrogens as well as upon exposure to polycyclic aromatic hydrocarbons (PAH) and contribute to estrogen and PAH carcinogenesis by genotoxic mechanisms.
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