Antiproliferative activity of 8-methoxypsoralen on DU145 prostate cancer cells under UVA and blue light | Zendy

Giulio Sturaro | Zendy; Giulia Cigolini | Zendy; Luca Menilli | Zendy; Fabio Cola | Zendy; Rosa Di Liddo | Zendy; Alessia Tasso | Zendy; Maria Teresa Conconi | Zendy; Giorgia Miolo | Zendy

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Antiproliferative activity of 8-methoxypsoralen on DU145 prostate cancer cells under UVA and blue light

Author(s) -

Giulio Sturaro,

Giulia Cigolini,

Luca Menilli,

Fabio Cola,

Rosa Di Liddo,

Alessia Tasso,

Maria Teresa Conconi,

Giorgia Miolo

Publication year - 2017

Publication title -

photochemical and photobiological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.699

H-Index - 101

eISSN - 1474-9092

pISSN - 1474-905X

DOI - 10.1039/c7pp00116a

Subject(s) - du145 , blue light , dna damage , chemistry , p38 mitogen activated protein kinases , prostate cancer , reactive oxygen species , cancer research , dna , mapk/erk pathway , microbiology and biotechnology , kinase , cancer , biochemistry , biology , optoelectronics , materials science , genetics , lncap

The use of photoactivatable 8-methoxypsoralen (8-MOP) as potential focal treatment towards prostate cancer cells is proposed here. Our results, obtained on isolated DNA and DU145 cells, indicate that blue light, besides UVA, is able to activate 8-MOP. When compared to UVA, blue light irradiation led to a modulation of the extent and the types of 8-MOP-DNA damage, specially cross-links, coupled to a still valuable antiproliferative effect. Our data suggest that the proapototic activity of 8-MOP is related not only to DNA damage and reactive oxygen species generation but also to the modulation of cell signalling pathways. In particular, a different activation of p38 and p44/42 mitogen-activated protein kinases was detected depending on the light wavelengths.

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