Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA | Zendy

Mostafa Kamal Masud | Zendy; Md. Nazmul Islam | Zendy; Md. Hakimul Haque | Zendy; Shunsuke Tanaka | Zendy; Vinod Gopalan | Zendy; Gürsel Alıcı | Zendy; NamTrung Nguyen | Zendy; Alfred K. Lam | Zendy; Md. Shahriar A. Hossain | Zendy; Yusuke Yamauchi | Zendy; Muhammad J. A. Shiddiky | Zendy

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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA

Author(s) -

Mostafa Kamal Masud,

Md. Nazmul Islam,

Md. Hakimul Haque,

Shunsuke Tanaka,

Vinod Gopalan,

Gürsel Alıcı,

NamTrung Nguyen,

Alfred K. Lam,

Md. Shahriar A. Hossain,

Yusuke Yamauchi,

Muhammad J. A. Shiddiky

Publication year - 2017

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c7cc04789d

Subject(s) - nanoporous , superparamagnetism , catalysis , materials science , nanotechnology , signal (programming language) , microrna , chemistry , computer science , physics , organic chemistry , magnetization , quantum mechanics , magnetic field , programming language , biochemistry , gene

This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe 2 O 3 NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).

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