Open AccessLong-term exposure of K562 cells to benzene metabolites inhibited erythroid differentiation and elevated methylation in erythroid specific genes
Author(s) -
Kai Tang,
Chaohui Yu,
Liang Jiang,
Meng Gong,
Wanlin Liu,
Y. Wang,
Ning Cui,
Wei Song,
Yingli Sun,
Yi Zhang
Publication year - 2016
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c6tx00143b
Subject(s) - methylation , k562 cells , gene , biology , chemistry , microbiology and biotechnology , biochemistry
We demonstrate that long-term and low-dose exposure to benzene metabolites inhibits hemin-induced erythroid differentiation of K562 cells, in which DNA methylation plays a role through depressing erythroid specific genes.
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