A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication | Zendy

Eugenie Nepovimová | Zendy; Jan Korábečný | Zendy; Rafael Doležal | Zendy; Thuy Duong Nguyen | Zendy; Daniel Jun | Zendy; Ondřej Soukup | Zendy; Markéta Pasdiorová | Zendy; Petr Jošt | Zendy; Ľubica Múčková | Zendy; Dávid Maliňák | Zendy; Lukáš Górecki | Zendy; Kamil Musílek | Zendy; Kamil Kuča | Zendy

Open Access

A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

Author(s) -

Eugenie Nepovimová,

Jan Korábečný,

Rafael Doležal,

Thuy Duong Nguyen,

Daniel Jun,

Ondřej Soukup,

Markéta Pasdiorová,

Petr Jošt,

Ľubica Múčková,

Dávid Maliňák,

Lukáš Górecki,

Kamil Musílek,

Kamil Kuča

Publication year - 2016

Publication title -

toxicology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.709

H-Index - 31

eISSN - 2045-4538

pISSN - 2045-452X

DOI - 10.1039/c6tx00130k

Subject(s) - organophosphate , acetylcholinesterase , organophosphate poisoning , chemical warfare agents , medicine , nerve agent , pharmacology , chemistry , enzyme , biology , engineering , biochemical engineering , pesticide , biochemistry , agronomy

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research