Open AccessThe inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine
Author(s) -
Xingyu Liu,
Jie Zhang,
Chen Zhang,
Bicheng Yang,
Limeng Wang,
Jun Zhou
Publication year - 2016
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c6tx00016a
Subject(s) - carcinogen , chemistry , nicotine , metabolism , cytochrome p450 , nat , enzyme , biochemistry , nitrosamine , context (archaeology) , stereochemistry , biology , medicine , computer network , paleontology , computer science
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is considered to be the most carcinogenic of the four tobacco-specific nitrosamines (TSNAs) and it needs to be metabolically activated to exert its carcinogenic effect on humans.
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