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4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is considered to be the most carcinogenic of the four tobacco-specific nitrosamines (TSNAs) and it needs to be metabolically activated to exert its carcinogenic effect on humans.

The inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine