Open AccessDirect reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides
Author(s) -
А. В. Аксенов,
Nicolai A. Aksenov,
Zarema V. Dzhandigova,
Дмитрий А. Аксенов,
Leonid G. Voskressensky,
Valentine G. Nenajdenko,
Michael Rubin
Publication year - 2016
Publication title -
rsc advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.746
H-Index - 148
ISSN - 2046-2069
DOI - 10.1039/c6ra21399e
Subject(s) - coupling (piping) , combinatorial chemistry , chemistry , computer science , materials science , metallurgy
A highly efficient one-pot method for the reductive coupling of indoles to nitrostyrenes in polyphosphoric acid doped with PCl3 was developed. This method allows direct and expeditious access to primary (indol-3-yl)acetamides, interesting as anti-cancer drug candidates.
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