Spiro-condensation of 5-methoxycarbonyl-1H-pyrrole-2,3-diones with cyclic enoles to form spiro substituted furo[3,2-c]-coumarins and quinolines | Zendy

Alexey Yu. Dubovtsev | Zendy; P. S. Silaichev | Zendy; М. А. Назаров | Zendy; М. V. Dmitriev | Zendy; А. Н. Масливец | Zendy; Michael Rubin | Zendy

Open Access

Spiro-condensation of 5-methoxycarbonyl-1H-pyrrole-2,3-diones with cyclic enoles to form spiro substituted furo[3,2-c]-coumarins and quinolines

Author(s) -

Alexey Yu. Dubovtsev,

P. S. Silaichev,

М. А. Назаров,

М. V. Dmitriev,

А. Н. Масливец,

Michael Rubin

Publication year - 2016

Publication title -

rsc advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.746

H-Index - 148

ISSN - 2046-2069

DOI - 10.1039/c6ra16889b

Subject(s) - electrophile , chemistry , pyrrole , nucleophile , condensation , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , physics , thermodynamics

Highly efficient spiro-condensation enabling cyclic enoles to act as 1,3-bis-nucleophiles in reaction with pyrrole-2,3-diones acting as 1,2-bis-electrophiles was developed. The corresponding furo[3,2-c]coumarins and furo[3,2-c]quinolines containing a spiro pyrrole fragment were obtained in high yields.

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