Formation of β-(1,3-1,6)-d-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages | Zendy

Atsushi Ikeda | Zendy; Motofusa Akiyama | Zendy; Kouta Sugikawa | Zendy; Kazuya Koumoto | Zendy; Yuta Kashijima | Zendy; Jiawei Li | Zendy; Toshio Suzuki | Zendy; Takeshi Nagasaki | Zendy

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Formation of β-(1,3-1,6)-d-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages

Author(s) -

Atsushi Ikeda,

Motofusa Akiyama,

Kouta Sugikawa,

Kazuya Koumoto,

Yuta Kashijima,

Jiawei Li,

Toshio Suzuki,

Takeshi Nagasaki

Publication year - 2017

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/c6ob02747d

Subject(s) - chemistry , glucan , fullerene , photodynamic therapy , stereochemistry , biophysics , biochemistry , organic chemistry , biology

[70]Fullerene was dissolved in water by complexation with β-1,3-glucan using a mechanochemical high-speed vibration milling apparatus. The photodynamic activity of β-1,3-glucan-complexed C 70 was highly dependent on the expression level of dectin-1 on the cell surfaces of macrophages. The photodynamic activity increased as a result of a synergistic effect between β-1,3-glucan-complexed 1'-acetoxychavicol acetate and the C 70 complex.

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