Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor | Zendy

Thomas Hanauer | Zendy; Richard J. Hopkinson | Zendy; Kamal Patel | Zendy; Yu Li | Zendy; Danilo Correddu | Zendy; Akane Kawamura | Zendy; Vijayalekshmi Sarojini | Zendy; Ivanhoe K. H. Leung | Zendy; Tobias Gruber | Zendy

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Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor

Author(s) -

Thomas Hanauer,

Richard J. Hopkinson,

Kamal Patel,

Yu Li,

Danilo Correddu,

Akane Kawamura,

Vijayalekshmi Sarojini,

Ivanhoe K. H. Leung,

Tobias Gruber

Publication year - 2017

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/c6ob02616h

Subject(s) - epigenetics , chemistry , receptor , histone , molecular recognition , computational biology , biochemistry , posttranslational modification , combinatorial chemistry , molecule , microbiology and biotechnology , biology , enzyme , dna , organic chemistry , gene

Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.

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