A ratiometric fluorescent sensor for the mitochondrial copper pool | Zendy

Clara Shen | Zendy; Jacek L. Kolanowski | Zendy; Carmen M.-N. Tran | Zendy; Amandeep Kaur | Zendy; Mia C. Åkerfeldt | Zendy; Matthew S. Rahme | Zendy; Trevor W. Hambley | Zendy; Elizabeth J. New | Zendy

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A ratiometric fluorescent sensor for the mitochondrial copper pool

Author(s) -

Clara Shen,

Jacek L. Kolanowski,

Carmen M.-N. Tran,

Amandeep Kaur,

Mia C. Åkerfeldt,

Matthew S. Rahme,

Trevor W. Hambley,

Elizabeth J. New

Publication year - 2016

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c6mt00083e

Subject(s) - copper , fluorescence , chemistry , mitochondrion , homeostasis , cisplatin , biophysics , microbiology and biotechnology , biochemistry , biology , organic chemistry , optics , genetics , physics , chemotherapy

Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(i). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.

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