Open AccessNew insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling
Author(s) -
Madhuresh Sumit,
Shuichi Takayama,
Jennifer J. Linderman
Publication year - 2016
Publication title -
integrative biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 70
eISSN - 1757-9708
pISSN - 1757-9694
DOI - 10.1039/c6ib00178e
Subject(s) - pulsatile flow , signal transduction , microfluidics , computational biology , biology , microbiology and biotechnology , chemistry , nanotechnology , endocrinology , materials science
A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.
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