Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform | Zendy

Max I. Bogorad | Zendy; Peter C. Searson | Zendy

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Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform

Author(s) -

Max I. Bogorad,

Peter C. Searson

Publication year - 2016

Publication title -

integrative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.853

H-Index - 70

eISSN - 1757-9708

pISSN - 1757-9694

DOI - 10.1039/c6ib00082g

Subject(s) - microvessel , kinetics , biophysics , chemistry , live cell imaging , doxorubicin , facilitated diffusion , diffusion , biomedical engineering , cell , angiogenesis , physics , medicine , biology , cancer research , biochemistry , surgery , membrane , chemotherapy , quantum mechanics , thermodynamics

The kinetics of solute transport across cell monolayers is complex, and often consists of multiple active transport processes in addition to passive diffusion. Here we demonstrate that mechanistic details of transport across biological barriers can be obtained from live cell imaging in a perfusable microvessel model with physiologically relevant geometry.

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