Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK | Zendy

Shawn P. Carey | Zendy; Zachary E. Goldblatt | Zendy; Karen E. Martin | Zendy; Bethsabe Romero | Zendy; Rebecca M. Williams | Zendy; Cynthia A. ReinhartKing | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK

Author(s) -

Shawn P. Carey,

Zachary E. Goldblatt,

Karen E. Martin,

Bethsabe Romero,

Rebecca M. Williams,

Cynthia A. ReinhartKing

Publication year - 2016

Publication title -

integrative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.853

H-Index - 70

eISSN - 1757-9708

pISSN - 1757-9694

DOI - 10.1039/c6ib00030d

Subject(s) - extracellular matrix , rac1 , microbiology and biotechnology , cell migration , biophysics , chemistry , extracellular , actin , matrix (chemical analysis) , cell , biology , signal transduction , biochemistry , chromatography

Fiber alignment within tumor-mimetic engineered collagen matrices drives FAK- and Rac1-dependent cellular anisotropy that promotes protrusions along fibers and suppresses off-axis protrusions to direct cell migration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research