Polyoxometalates as artificial nucleases: hydrolytic cleavage of DNA promoted by a highly negatively charged ZrIV-substituted Keggin polyanion | Zendy

Thị Kim Nga Lương | Zendy; I. Govaerts | Zendy; Johan Robben | Zendy; Pavletta Shestakova | Zendy; Tatja. ParacVogt | Zendy

Open Access

Polyoxometalates as artificial nucleases: hydrolytic cleavage of DNA promoted by a highly negatively charged Zr^IV-substituted Keggin polyanion

Author(s) -

Thị Kim Nga Lương,

I. Govaerts,

Johan Robben,

Pavletta Shestakova,

Tatja. ParacVogt

Publication year - 2016

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c6cc08555e

Subject(s) - cleavage (geology) , hydrolysis , dna , chemistry , ion , crystallography , combinatorial chemistry , stereochemistry , materials science , organic chemistry , biochemistry , fracture (geology) , composite material

A highly negatively charged binuclear Zr IV -substituted Keggin polyoxometalate [{α-PW 11 O 39 Zr(μ-OH)(H 2 O)} 2 ] 8- (ZrK 2 : 2) has been shown to promote the hydrolytic cleavage of phosphoester bonds in the supercoiled plasmid pUC19 DNA under physiological pH and temperature, giving relaxed and linear forms of pUC19 as hydrolysis products. The interaction between ZrK 2 : 2 and DNA was experimentally proven by circular dichroism (CD) spectroscopy and 31 P diffusion ordered NMR spectroscopy.

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